PROPOLEOS Y HONGOS
(FUNGUS)
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Items 1 - 47 of 47 |
One page. |
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1:
Acta
Pharm. 2005 Dec;55(4):423-30. |
Flavonoid analysis and antimicrobial activity of commercially available
propolis products.
Kosalec I, Pepeljnjak S, Bakmaz M, Vladimir-Knezevic S.
Department of Microbiology, Faculty of Pharmacy and Biochemistry, University of
Zagreb, Zagreb, Croatia. ikosalec@pharma.hr
Propolis ethanolic solutions are the most used propolis products on the market
for the treatment of minor ulcers in the mouth, angina, thrush or skin
infections. Since it is still an unofficial drug in pharmacy, we analyzed the
contents of flavonoids in ten commercially available ethanolic solutions of
propolis from the Croatian market using two complementary colorimetric methods.
Antimicrobial activities, determined with the diffusion method, against six
bacterial species (Bacillus subtilis NCTC 8236, Staphylococcus aureus ATCC
25923, Streptococcus pyogenes ATCC 12204, Enterococcus faecalis ATCC 29212,
Escherichia coli ATCC 10536, Pseudomonas aeruginosa ATCC 27853, and one
yeast-like fungus Candida albicans ATCC 10231 were compared. Results of
flavonoids analysis suggested that the contents of flavones and flavonols in
the products were uniform and ranged from 0.14 to 0.41%, but the content of
flavanones varied greatly from 0.43 to 18.78%. Total flavonoid content, as the
sum of two colorimetric methods, in propolis products was between 0.78 and
18.92%, and most products had the flavonoids content below 9%. All products
with the total flavonoids content above 1% showed antimicrobial activity
against the four Gram-positive bacterial species tested, and against P.
aeruginosa and the yeast-like fungus C. albicans. Total flavonoids contents,
expressed as the sum of two colorimetric methods, could be useful methods for
estimating the flavonoid contents of propolis products. Our results indicate
that the quality of commercially available propolis products requires
verification.
PMID: 16375832 [PubMed - in process]
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2:
Phytother
Res. 2005 Jul;19(7):652-4. |
Oral candidiasis treatment with Brazilian ethanol propolis extract.
Santos VR, Pimenta FJ, Aguiar MC, do Carmo MA, Naves MD, Mesquita RA.
Department
of Clinical Pathology and Surgery, Laboratory of Microbiology, Dentistry
School, Minas Gerais Federal University, Campus da Pampulha, Belo Horizonte,
Minas Gerais, Brazil, CEP 31.270-901. vegneer2003@yahoo.com.br
The Brazilian commercial ethanol propolis extract, also formulated to ensure
physical and chemical stability, was found to inhibit oral candidiasis in 12
denture-bearing patients with prosthesis stomatitis candidiasis association.
PMID: 16161031 [PubMed - indexed for MEDLINE]
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3:
Microbiol
Res. 2005;160(2):189-95. |
Chemical compositions and antimicrobial activities of four different
Anatolian propolis samples.
Uzel A, Sorkun K, Oncag O, Cogulu D, Gencay O, Salih B.
Department
of Biology, Faculty of Sciences, Ege University, Basic and Industrial
Microbiology Section, Bornova-Izmir 35100, Turkey. uzel@sci.ege.edu.tr
Propolis means a gum that is gathered by bees from various plants. It is known
for its biological properties, having antibacterial, antifungal and healing
properties. The aims of this study were to evaluate the antimicrobial activity
of four different Anatolian propolis samples on different groups of
microorganisms including some oral pathogens and comparison between their
chemical compositions. Ethanol extracts of propolis (EEP) were prepared from
four different Anatolian propolis samples and examined whether EEP inhibit the
growth of the test microorganisms or not. For the antimicrobial activity
assays, minimum inhibitory concentrations (MIC) were determined by using
macrodilution method. The MIC values of the most effective propolis (TB) were 2
microg/ml for Streptococcus sobrinus and Enterococcus faecalis, 4 microg/ml for
Micrococcus luteus, Candida albicans and C. krusei, 8 microg/ml for
Streptococcus mutans, Staphylococcus aureus, Staphylococcus epidermidis and
Enterobacter aerogenes, 16 microg/ml for Escherichia coli and C. tropicalis and
32 microg/ml for Salmonella typhimurium and Pseudomonas aeruginosa. The
chemical compositions of EEP's were determined by high-temperature
high-resolution gas chromatography coupled to mass spectrometry. The main
compounds of four Anatolian propolis samples were flavonoids such as
pinocembrin, pinostropin, isalpinin, pinobanksin, quercetin, naringenin,
galangine and chrysin. Although propolis samples were collected from different
regions of Anatolia all showed significant antimicrobial activity against the
Gram positive bacteria and yeasts. Propolis can prevent dental caries since it
demonstrated significant antimicrobial activity against the microorganisms such
as Streptococcus mutans, Streptococcus sobrinus and C. albicans, which involves
in oral diseases.
PMID: 15881836 [PubMed - indexed for MEDLINE]
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4:
J
Ethnopharmacol. 2005 May 13;99(1):69-73. |
Chemical composition and antibacterial activity of propolis collected by
three different races of honeybees in the same region.
Silici S, Kutluca S.
Erciyes University, S.Cikrikcioglu Vocational College, Department of
Beekeeping, 38039 Kayseri, Turkey. silicis@erciyes.edu.tr
The chemical analysis and antibacterial activity of three types of propolis collected
three different races of Apis mellifera bee in the same apiary were
investigated. Propolis samples were investigated by GC/MS, 48 compounds were
identified 32 being new for propolis. The compounds identified indicated that
the main plant sources of propolis were Populus alba, Populus tremuloides and
Salix alba. The antimicrobial activity against Staphylococcus aureus,
Escherichia coli, Pseudomonas aeruginosa and Candida albicans was evaluated. Ethanolic
extracts of propolis samples showed high antibacterial activity against
Gram-positive cocci (Staphylococcus aureus), but had a weak activity against
Gram-negative bacteria (Escherichia coli and Pseudomonas aeruginosa) and yeast
(Candida albicans). Propolis sample collected by Apis mellifera caucasica showed
a higher antibacterial activity than collected by Apis mellifera anatolica and
Apis mellifera carnica.
PMID: 15848022 [PubMed - indexed for MEDLINE]
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5:
Mycoses.
2005 May;48(3):205-10. |
Comparison of in vitro activities of antifungal drugs and ethanolic
extract of propolis against Trichophyton rubrum and T. mentagrophytes by using
a microdilution assay.
Koc AN, Silici S, Ayangil D, Ferahbas A, Cankaya S.
Medical Faculty, Department of Microbiology, Erciyes University, Kayseri,
Turkey.
The in vitro activities of propolis against 29 strains of dermatophytes were
compared with those of terbinafine, itraconazole, ketoconazole, and
fluconazole. Minimal inhibitory concentrations (MICs) were determined according
to a National Committee for Clinical Laboratory Standards broth microdilution
method. Among the systemic antifungals tested, terbinafine was the most potent.
Propolis showed important antifungal activity and it merits further
investigation as a potentially useful agent for the treatment of
dermatophytosis.
PMID: 15842339 [PubMed - indexed for MEDLINE]
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6:
Mikrobiol
Z. 2004 Nov-Dec;66(6):53-7. |
[Antimicrobial properties of bee preparations in ointment form]
[Article in Ukrainian]
Postoienko VO, Senchuhova NA, Postoienko OM, Patyka VP.
High antimicrobial activity apiphytopreparation in the form of the ointments
containing pine turpentine, different concentration of propolis (from 4 to 20
%), honey and carotene oil from carrots (ointment N 4) has been. While testing
by the method of diffusion in agar all the studied apiphytopreparation
suppressed growth of Staphylococcus aureus, Bacillus subtilis, Saccharomyces
cerevisiae, Micrococcus luteus, M. roseus. This effect increased with propolis
content increase in the content of ointments. Bee honey and carotene oil
intensified their antimicrobial activity. The latter was caused by the action
of phenolic compounds, ether oils and other biologically active substances--the
apiculture and vegetative raw material.
PMID: 15765871 [PubMed - indexed for MEDLINE]
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7:
Oral
Health Prev Dent. 2003;1(1):29-35. |
Propolis extract as an adjuvant to periodontal treatment.
Gebaraa EC, Pustiglioni AN, de Lima LA, Mayer MP.
Department of Microbiology, Institute of Biomedical Sciences, University of Sao
Paulo, Sao Paulo, Brazil. gebar@uol.com.br
PURPOSE: The aim of this study was to evaluate the effect of subgingival
irrigation with propolis extract by clinical and microbiological parameters. MATERIALS
AND METHODS: Twenty patients diagnosed with chronic periodontitis presenting
three non-adjacent teeth with deep pockets were selected. After scaling and
root planing, the selected periodontal sites were submitted to one of the
following treatments: irrigation with a hydro alcoholic solution of propolis
extract twice/week for two weeks (group A); irrigation with a placebo twice/week
for two weeks (group B); or no additional treatment (C). Subgingival plaque
sampling and scaling and root planing were performed two weeks after clinical
data recording. Two weeks later irrigation procedures were started (Baseline).
Microbiological and clinical data were collected at baseline, and after 4, 6
and 24 weeks. RESULTS: A decrease in total viable counts of anaerobic bacteria
(p=0.007), an increase in the proportion of sites with low levels (< or =
10(3) cfu/mL) of Porphyromonas gingivalis (p=0.005), and a decrease in the
number of sites with detectable presence of yeasts (p=0.000) were observed in
group A sites when compared to group B and C sites. Propolis treatment did not
lead to an increase in organisms such as coagulase positive Staphylococci and
Pseudomonas spp. 24 weeks after treatment there was an increased proportion of
sites showing probing depth (PD) < or =
PMID: 15643746 [PubMed - indexed for MEDLINE]
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8:
Nahrung. 2004
Jun;48(3):188-94. |
Inhibitory effect of pollen and propolis extracts.
Ozcan M, Unver A, Ceylan DA, Yetisir R.
Department of Food Engineering, Faculty of Agriculture, Selcuk University,
Konya, Turkey. mozcan@selcuk.edu.tr
Bee pollen and propolis were collected from Apis mellifera colonies in five
regions of Turkey. The antifungal properties of methanol extracts of pollen and
propolis (2% and 5% concentrations) were determined on Alternaria alternata and
Fusarium oxysporium f. sp. melonis. The least active concentration towards the
tested fungi was 2% concentration of both extracts. The inhibitory effect of
all propolis extracts on growth of F. oxysporium and A. alternata were
generally higher when compared with pollen extracts. The growth of A. alternata
and F. oxysporium were not affected at both concentrations of pollens. However,
F. oxysporium against propolis extracts was more sensitive than A. alternata (P
< 0.01). None of the pollen extracts tested completely inhibited mycelial
growth of fungi used in our experiment. Percent inhibition of both pollen
concentrations against A. alternata and F. oxysporium was lower than 50%. However,
both concentrations of Alanya and Beysehir propolis extracts were 100%
effective on mycelial growth of F. oxysporium until the 7th day of incubation
(P < 0.01). 2% Alanya and Beysehir pollen extracts completely stimulated
mycelial growth of F. oxysporium on the 7th day of incubation. Both
concentrations of propolis extract showed more than 50% inhibition against E.
oxysporium. It is suggested that high concentrations ofpropolis extract could
be used as an antifungal agent against tested fungi.
PMID: 15285109 [PubMed - indexed for MEDLINE]
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9:
Planta
Med. 2004 Jun;70(6):515-9. |
Chemical analysis and antimicrobial activity of Greek propolis.
Melliou E, Chinou I.
Division of Pharmacognosy and Natural Products Chemistry, Department of
Pharmacy, University of Athens, 157-71 Athens, Greece.
One new 2,3-dihydroflavone derivative, 7- O-prenylstrobopinin, and 25 known
diterpenes and phenolic compounds were identified from the n-butanol extract of
Greek propolis. This is the first time that diterpenes have been isolated from
propolis of European origin, while six of the known compounds are reported as
propolis constituents for the first time. The structures of the isolated
compounds were determined by spectroscopic methods, mainly by the concerted
application of 1D, 2D NMR techniques (HMQC, HMBC, NOESY) and mass spectrometry.
The studied sample and the isolated compounds were tested for their
antimicrobial activity against Gram (+/-) bacteria and fungi and five of them
exhibited strong activities.
PMID: 15229802 [PubMed - indexed for MEDLINE]
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10:
J Med
Food. 2004 Spring;7(1):114-6. |
Inhibition of Aspergillus parasiticus NRRL 2999 by pollen and propolis
extracts.
Ozcan M.
Department of Food Engineering, Faculty of Agriculture, Selcuk University,
Konya, Turkey. mozcan@selcuk.edu.tr
The inhibitory effects on mycelial growth of Aspergillus parasiticus strain
NRRL 2998 of pollen and propolis extracts from different regions of Turkey were
investigated in culture media. The least active concentration towards the
tested fungus was 2% of both extracts. But, the inhibitory effects of all
propolis extracts on mycelial growth were higher when compared with pollen
extracts. While the effect of a 5% level of Antakya propolis extract increased
with increasing incubation period, the antifungal effect of pollen extract from
the same region on mycelial growth was less than that of the control group. As
a result, none of the extracts tested completely inhibited mycelial growth. The
highest inhibition rate was established at the 5% level of Taskent and Alanya
propolis samples.
PMID: 15117563 [PubMed - indexed for MEDLINE]
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11:
J Med
Food. 2004 Spring;7(1):90-4. |
An in vitro study on antimicrobial activity of propolis from Mugla
province of Turkey.
Ugur A, Arslan T.
Department of Biology, Faculty of Arts and Sciences, Mugla University,
Kotekli-Mugla, Turkey. augur@mu.edu.tr
Antibacterial and antifungal activities of acetone and dimethyl sulfoxide
(DMSO) extracts of 45 different propolis samples from the Mugla province of
Turkey were investigated. Antimicrobial activity of propolis varied depending
on propolis sample, dosage of propolis, and the extraction solvents for all
test microorganisms. Antimicrobial activity of all propolis samples increased
with increasing dosage without reaching a plateau at the highest dosage tested.
Except for Brucella melitensis, the DMSO extracts of all propolis samples were
more active than the acetone extracts of the same samples. For B. melitensis,
the acetone extracts of all propolis samples showed greater activity. The most
sensitive microorganism to propolis was Shigella sonnei in the gram-negative
group and Streptococcus mutans in the gram-positive group. The least sensitive
microorganism was Candida albicans. A control test run with standard
antibiotics revealed that propolis samples from the Mugla province of Turkey
has a similar or greater inhibitory effect on S. mutans, Salmonella typhi,
Pseudomonas aeruginosa, S. sonnei, and C. albicans growth.
PMID: 15117559 [PubMed - indexed for MEDLINE]
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12:
Lett
Appl Microbiol. 2004;38(2):87-92. |
Chemical composition and microbicidal activity of extracts from
Brazilian and Bulgarian propolis.
Salomao K, Dantas AP, Borba CM, Campos LC, Machado DG, Aquino Neto FR,
de Castro SL.
Dept. de
Ultra-estrutura e Biologia Celular Dept. de Micologia Dept. de Bacteriologia,
Instituto Oswaldo Cruz, FIOCRUZ, Rio de Janeiro, Brazil. solange@ioc.fiocruz.br
AIMS: The chemical composition of ethanol extracts from a Brazilian (Et-Bra)
and a Bulgarian (Et-Blg) propolis, and their activity against the protozoan
Trypanosoma cruzi, several fungi and bacteria species were determined. METHODS
AND RESULTS: The chemical composition was determined by high temperature high
resolution gas chromatography coupled to mass spectrometry. Microbiological
activity was assayed in vitro against T. cruzi, Candida albicans, Sporothrix
schenckii, Paracoccidioides brasiliensis, Neisseria meningitidis, Streptococcus
pneumoniae and Staphylococcus aureus. CONCLUSIONS: Et-Bra and Et-Blg, although
with totally distinct compositions, were active against T. cruzi and the three
species of fungi. Et-Blg was more effective than Et-Bra against bacteria,
particularly N. meningitidis and Strep. pneumoniae. SIGNIFICANCE AND IMPACT OF
THE STUDY: Although with different classes of components, both propolis
extracts showed microbicidal activity. For the bactericidal activity it was
possible to establish a positive correlation with the high content of
flavonoids of the Bulgarian extract.
PMID: 14746537 [PubMed - indexed for MEDLINE]
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13:
Microbiol
Res. 2003;158(4):353-7. |
In vitro antimicrobial activity of propolis and synergism between
propolis and antimicrobial drugs.
Stepanovic S, Antic N, Dakic I, Svabic-Vlahovic M.
Department of Bacteriology, Institute of Microbiology and Immunology, School of
Medicine, University of Belgrade, Dr Subotica 1, 11000 Belgrade, Serbia.
stepan@afrodita.rcub.bg.ac.yu
The aim of this study was to investigate antimicrobial properties of ethanolic
extract of 13 propolis (EEP) samples from different regions of Serbia against
39 microorganisms (14 resistant or multiresistant to antibiotics), and to
determine synergistic activity between antimicrobials and propolis. Antimicrobial
activity of propolis samples was evaluated by agar diffusion and agar dilution
method. The synergistic action of propolis with antimicrobial drugs was assayed
by the disc diffusion method on agar containing subinhibitory concentrations of
propolis. Obtained results indicate that EEP, irrespectively of microbial
resistance to antibiotics, showed significant antimicrobial activities against
Gram-positive bacteria (MIC 0.078%-1.25% of EEP) and yeasts (0.16%-1.25%),
while Gram-negative bacteria were less susceptible (1.25%-->5%). Enterococcus
faecalis was the most resistant Gram-positive bacterium, Salmonella spp. the
most resistant Gram-negative bacteria, and Candida albicans the most resistant
yeast. EEP showed synergism with selected antibiotics, and displayed ability to
enhance the activities of antifungals. The shown antimicrobial potential of
propolis alone or in combination with certain antibiotics and antifungals is of
potential medical interest.
PMID: 14717457 [PubMed - indexed for MEDLINE]
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14:
Mutat Res.
2003 Nov;544(2-3):195-201. |
Dietary components may prevent mutation-related diseases in humans.
Ribeiro LR, Salvadori DM.
Programa de Pos-Graduacao
Since it is
not always possible to reduce human exposure to mutagens, attempts have been
directed to identify potential antimutagens and anticarcinogens for use in
protecting the population against environmental disease. The purpose of this
paper is to provide the reader with information about the antimutagenic and
anticarcinogenic potentials of some dietary constituents and foods widely
consumed in Brazil, and to reinforce diet as a key factor in determining
genomic stability and preventing human diseases. In this report, we have
summarized data that show interactive effects between some dietary components
and specific chemical mutagens or carcinogens using in vitro and in vivo short-
or medium-term assays. The summary indicates that certain dietary compounds may
be useful agents for disease prevention.
Publication Types:
·
Review
PMID: 14644321 [PubMed - indexed for MEDLINE]
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15:
J
Chemother. 2003 Oct;15(5):454-60. |
Effect of propolis on virulence factors of Candida albicans.
D'Auria FD, Tecca M, Scazzocchio F, Renzini V, Strippoli V.
Institute of Microbiology, Faculty of Pharmacy, University of Rome La Sapienza,
P.le A.Moro, 5, 00185 Rome, Italy. felicia.d'auria@uniroma1.it
Propolis is a resinous substance collected by honeybees from plant sources. Its
antimicrobial activity has been well documented but little is specifically
known about its activity on virulence factors of Candida albicans. The aim of
this work was therefore to evaluate in vitro the propolis effect on
yeast-mycelial conversion (Y-M), extracellular phospholipase activity and
fungal adhesion to epithelial cells. The two propolis samples used
significantly inhibited the C. albicans strains tested, showing a rapid
(between 30 seconds and 15 minutes), dose-dependent cytocidal activity and an
inhibitory effect on Y-M conversion at a concentration of 0.22 mg/ml. Moreover,
the hyphal length was reduced even at lower propolis concentration. Propolis
also caused a dose- and time-dependent inhibition of phospholipase activity. No
clear effect was shown on adherence to buccal epithelial cells and surface
structure hydrophobicity, but damage to the plasma membrane structure was
demonstrated with the Propidium Iodide test.
PMID: 14598937 [PubMed - indexed for MEDLINE]
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16:
J
Ethnopharmacol. 2003 Oct;88(2-3):189-93. |
Flavonoids and trypanocidal activity of Bulgarian propolis.
Prytzyk E, Dantas AP, Salomao K, Pereira AS, Bankova VS, De Castro SL, Neto FR.
Ladetec, Instituto de Quimica, Universidade Federal do Rio de Janeiro, Ilha do
Fundao, Cidade Universitaria, CT Bl. A, 21949-900 Rio de Janeiro, RJ, Brazil.
Acetone and ethanol extracts of two Bulgarian propolis samples (Bur and Lov)
were investigated by high temperature high resolution gas chromatography
coupled to mass spectrometry (HT-HRGC-MS), and their activity against
Trypanosoma cruzi was evaluated. The ethanol extracts--Et-Bur and
Et-Lov--showed similar composition, with a high content of flavonoids, and
strong inhibitory activity against T. cruzi proliferative epimastigotes, which
were more susceptible than trypomastigotes. In the presence of blood, the
activity of Et-Bur or Et-Lov against trypomastigotes was similar to that of the
standard drug, crystal violet. Both extracts also showed similar and
significant activity against Staphylococcus aureus and Candida albicans, while
being inactive against Escherichia coli. The acetone extract, Ket-Bur, was more
active than Et-Bur against both forms of T. cruzi.
PMID: 12963141 [PubMed - indexed for MEDLINE]
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17:
J
Ethnopharmacol. 2003 May;86(1):69-73. |
Antimicrobial activity of propolis samples from two different regions of
Anatolia.
Kartal M, Yildiz S, Kaya S, Kurucu S, Topcu G.
Department of Pharmacognosy, Faculty of Pharmacy, Ankara University, 06100
Ankara, Turkey. kartal@pharmacy.ankara.edu.tr
Antimicrobial activity of two propolis samples from Kazan and Marmaris regions
in Turkey were investigated by the disc diffusion method. Antimicrobial
activity was tested with four different ethanolic extracts (30, 50, 70, and 96%
ethanol) of each sample against seven Gram positive, four Gram negative
bacteria and one fungus culture. The activity was found to be mainly due to
caffeic acid and its esters. An isomeric mixture containing 3,3-dimethylallyl
caffeate, and isopent-3-enyl caffeate was isolated from Kazan propolis samples.
PMID: 12686444 [PubMed - indexed for MEDLINE]
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18: Int J Syst Evol Microbiol. 2003
Jan;53(Pt 1):339-43. |
Starmerella meliponinorum sp. nov., a novel ascomycetous yeast species
associated with stingless bees.
Teixeira AC, Marini MM, Nicoli JR, Antonini Y, Martins RP, Lachance MA, Rosa CA.
Departamento de Microbiologia, ICB, CP 486, Universidade Federal de Minas
Gerais, Belo Horizonte, MG, 31270-901, Brazil.
Thirty-two
strains of the novel species Starmerella meliponinorum sp. nov. were isolated
from various substrates associated with three stingless bee species (tribe
Meliponini) in Brazil and one in Costa Rica. The strains were found in garbage
pellets (faecal material, discarded pollen or food, etc.), pollen provisions,
adult bees, honey and propolis of Tetragonisca angustula, in honey from
Melipona quadritasciata and in adults of Melipona rufiventris and Trigona
fulviventris. The sequence of the D1/D2 domains of the large-subunit rDNA
showed that the novel species belongs to the Starmerella clade and is most
closely related to Candida etchellsii, although the two differ in their
sequences by 7% base substitutions. S. meliponinorum is homothallic and
assimilates few carbon sources. Nitrate is utilized as a sole nitrogen source. The
type strain of S. meliponinorum is strain UFMG-01-J26.1T (=CBS 9117T).
PMID: 12656193 [PubMed - indexed for MEDLINE]
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19:
Lett
Appl Microbiol. 2002;35(3):203-7. |
Comparative study of in vitro methods used to analyse the activity of
propolis extracts with different compositions against species of Candida.
Sawaya AC, Palma AM, Caetano FM, Marcucci MC, da Silva Cunha IB,
Araujo CE, Shimizu MT.
Universidade Sao Francisco, Centro de Ciencias Biologicas e da Saude, Braganca
Paulista, SP, Brazil.
AIMS:
Propolis is known for its activity against micro-organisms and different in
vitro assays have been used to evaluate this activity, frequently with
contradictory results. METHODS AND RESULTS: Brazilian propolis from the state
of Sao Paulo was extracted by maceration using different concentrations of
ethanol and water. The resultant extracts were analysed by chromatographic
methods. Several microbiological methods were compared to determine which one
best evaluated the activity of the propolis extracts against species of
Candida, with average minimal inhibitory concentration values between 6 and 12
mg ml(-1). CONCLUSIONS: Agar dilution in plates showed the clearest results.
These were in agreement with the chromatographic analyses, which also
identified the active substances. SIGNIFICANCE AND IMPACT OF THE STUDY:
Although the active substances identified in this sample are typical of
Brazilian propolis, their activity against Candida had not been recognized
previously, demonstrating the importance of standardizing the correct
combination of microbiological and chromatographic analyses.
Publication Types:
PMID: 12180941 [PubMed - indexed for MEDLINE]
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20:
Z
Naturforsch [C]. 2002 Mar-Apr;57(3-4):395-402. |
Egyptian propolis: 3. Antioxidant, antimicrobial activities and chemical
composition of propolis from reclaimed lands.
Hegazi AG, Abd El Hady FK.
Department of Parasitology, National Research Center, Dokki, Giza, Egypt.
ahmedgaffer@mailer.suc.eun.eg
The free radical scavenging effect of two propolis samples collected from
reclaimed land, Egypt as well as of vitamin C and caffeic acid in
1,1-diphenyl-2-picrylhydrazyl (DPPH) free radical system was determined. The
antimicrobial (Staphylococcus aureus; Escherichia coli and Candida albicans)
activity was also investigated. The results of the free radical scavenging
effect of El-Saff and Ismailia propolis showed a concentration-dependent
activity. The antioxidant activity was varied according to the examined
material. It was obvious that caffeic acid and vitamin C showed the highest
activity if compared with the propolis samples. El- Saff propolis had a higher
antioxidant activity than Ismailia propolis, it showed a higher antibacterial
activity against Staphylococcus aureus and a higher anti-fungal activity
against Candida albicans. While the Ismailia propolis had a higher
antibacterial activity against Escherichia coli, than El-Saff propolis. The
chemical composition of propolis samples was investigated by GC/MS, where 75
compounds were identified, 22 being new for propolis. The Ismailia propolis was
characterized by the presence of a highly significant amount of aromatic acid
esters (47.3%) and triterpenoids (17.3%), while El-Saff propolis contained 3% and
1.9% respectively. The new esters belonged to 4-methoxyhydrocinnamic acid,
hydroferulic acid and ferulic acid. El-Saff propolis had a very high
significant amount (27%) of 2,6-bis-(pentanyloxy)-4-pentanylphenethanol, which
is also a new compound for propolis.
PMID: 12064746 [PubMed - indexed for MEDLINE]
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21:
Z
Naturforsch [C]. 2002 Mar-Apr;57(3-4):386-94. |
Egyptian propolis: 2. Chemical composition, antiviral and antimicrobial
activities of East Nile Delta propolis.
Abd El Hady FK, Hegazi AG.
Department of Chemistry of Natural Products, National Research Center, Dokki,
Giza, Egypt.
Three propolis samples from East Nile Delta, Egypt were collected. Propolis
samples were investigated by GC/MS,103 compounds were identified, 20 being new
for propolis. Dakahlia propolis was a typical poplar propolis but it contained
two new caffeate esters and two new triterpenoids. Ismailia propolis was
characterized by the presence of new triterpenic acid methyl esters and it did
not contain any aromatic acids, esters and flavonoids. Sharkia propolis was
characterized by the presence of caffeate esters only, some di- and
triterpenoids. The antiviral (Infectious Bursal Disease Virus and Reo-Virus)
and antimicrobial (Staphylococcus aureus; Escherichia coli and Candida
albicans) activities of propolis samples were investigated. Dakahlia propolis
showed the highest antiviral activity against Infectious Bursal Disease Virus
(IBDV) and the highest antibacterial activity against Escherichia coli and the
highest antifungal activity against Candida albicans. While Ismailia propolis
had the highest antiviral activity against Reo-virus. Sharkia propolis showed
the highest antibacterial activity against Staphylococcus aureus and moderate
antiviral activity against infectious bursal disease virus and reovirus.
PMID: 12064745 [PubMed - indexed for MEDLINE]
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22:
J Oral
Sci. 2002 Mar;44(1):41-8. |
Effect of commercial ethanol propolis extract on the in vitro growth of
Candida albicans collected from HIV-seropositive and HIV-seronegative Brazilian
patients with oral candidiasis.
Martins RS, Pereira ES Jr,
Lima SM, Senna MI, Mesquita RA, Santos VR.
Department
of Clinical Pathology and Surgery, School of Dentistry, Minas Gerais Federal
University, Belo Horizonte, Brazil.
The present study assessed the susceptibility of Candida albicans strains,
collected from HIV-positive patients with oral candidiasis, to a commercial 20%
ethanol propolis extract (EPE) and compare it to the inhibitory action of the
standardized antifungal agents nystatin (NYS), clotrimazole (CL), econazole
(EC), and fluconazole (FL). Twelve C. albicans strains collected from
HIV-positive patients with oral candidiasis were tested. The inhibition zones
were measured with a pachimeter and the results are reported as means and
standard deviation (M +/- SD). Data were analyzed statistically by the
non-parametric Kruskal-Wallis test. EPE inhibited all the C. albicans strained
tested. No significant difference was observed between the results obtained
with NYS and EPE, while significant differences were observed between EPE and
other antifungals. The C. albicans strains tested showed resistance to the
remaining antifungal agents. The propolis extract used in this study inhibited
the in vitro growth of C. albicans collected from HIV-seropositive Brazilian
patients, creating/forming inhibition zones like those ones formed by NYS. This
fact suggests that commercial EPE could be an alternative medicine in the
treatment of candidiasis from HIV-positive patients. However, in vivo studies
of the effect of EPE are needed to determine its possible effects on the oral
mucosa.
PMID: 12058869 [PubMed - indexed for MEDLINE]
|
23:
J
Ethnopharmacol. 2002 Mar;79(3):331-4. |
Effects of propolis from Brazil and Bulgaria on fungicidal activity of
macrophages against Paracoccidioides brasiliensis.
Murad JM, Calvi SA, Soares AM, Bankova V, Sforcin JM.
Department of Microbiology and Immunology, Biosciences Institute, IB-UNESP,
18618-000 Botucatu, SP, Brazil
Paracoccidioidomycosis is the most important systemic mycosis in Latin America.
Its etiological agent, Paracoccidoides brasiliensis, affects individuals living
in endemic areas through inhalation of airborne conidia or mycelial fragments. The
disease may affect different organs and systems, with multiple clinical
features, with cell-mediated immunity playing a significant role in host
defence. Peritoneal macrophages from BALB/c mice were stimulated with Brazilian
or Bulgarian propolis and subsequently challenged with P. brasiliensis. Data
suggest an increase in the fungicidal activity of macrophages by propolis
stimulation, independently from its geographic origin.
PMID: 11849837 [PubMed - indexed for MEDLINE]
|
24:
Mycoses.
2001 Nov;44(9-10):375-8. |
Antifungal activity of propolis on different species of Candida.
Ota C, Unterkircher C,
Fantinato V, Shimizu MT.
Dental School, UNESP, Sao Jose dos Campos, SP, Brasil.
Propolis is a resinous material collected by bees from the buds or other parts
of plants. It is known for its biological properties, having antibacterial,
antifungal and healing properties. The antifungal activity of propolis was
studied in sensitivity tests on 80 strains of Candida yeasts: 20 strains of
Candida albicans, 20 strains of Candida tropicalis, 20 strains of Candida
krusei and 15 strains of Candida guilliermondii. The yeasts showed a clear
antifungal activity with the following order of sensitivity: C. albicans >
C. tropicalis > C. krusei > C. guilliermondii. Patients with full
dentures who used a hydroalcoholic propolis extract showed a decrease in the
number of Candida.
PMID: 11766101 [PubMed - indexed for MEDLINE]
|
25:
Z
Naturforsch [C]. 2001 Jul-Aug;56(7-8):593-6. |
New bioactive chalcones in
propolis from El Salvador.
Popova M, Bankova V, Spassov S, Tsvetkova I, Naydenski C, Silva MV, Tsartsarova M.
Institute of Organic Chemistry with Centre of Phytochemistry, Bulgarian Academy
of Sciences, Sofia.
2',3'-Dihydroxy-4,4'-dimethoxychalcone (1) and
2',3',4-trihydroxy-4'-methoxy-chalcone, two new chalcones, were isolated from
propolis from El Salvador. The compounds showed significant antibacterial and
antifungal activity and moderate toxicity to Artemia salina nauplii.
PMID: 11531095 [PubMed - indexed for MEDLINE]
|
26:
Z
Naturforsch [C]. 2001 Jan-Feb;56(1-2):82-8. |
Egyptian propolis:
1-antimicrobial activity and chemical composition of Upper Egypt propolis.
Hegazi AG, El Hady FK.
Department of Parasitology, National Research Center, Dokki, Giza, Egypt.
ahmedgaffer@mailer.suc.eun.eg
The antimicrobial activity of four propolis samples collected from Upper Egypt
against Staphylococcus aureus; Escherichia coli and Candida albicans was
evaluated. There was a variation in the antimicrobial activity according to the
propolis origin. Banisweif propolis showed the highest antimicrobial activity
against Staphylococcus aureus, Escherichia coli and Candida albicans, but
Fayoum propolis had moderate activity against all tested pathogens. Propolis
collected from Assiut and Souhag gave lower antimicrobial activity. Propolis
samples were investigated by GC/MS, 71 compounds were identified, 14 being new
for propolis. Banisweif propolis is characterized by the presence of 7 caffeate
esters and 4 triterpenoids. Fayoum propolis showed the highest amount of lactic
acid and the presence of 3 chalcones. But Assiut propolis is characterized by the
presence of 4 prenylated coumarates. Souhag propolis is characterized by the
presence of 5 aliphatic dicarboxylic acids and some other new compounds to
propolis.
PMID: 11302219 [PubMed - indexed for MEDLINE]
|
27:
J
Chemother. 2000 Oct;12(5):390-5. |
Erratum in:
·
J Chemother 2001
Feb;13(1):102.
In vitro antimicrobial
activity of propolis dry extract.
Drago L, Mombelli B, De Vecchi E, Fassina MC, Tocalli L, Gismondo MR.
Clinical Microbiology, L. Sacco Teaching Hospital, University of Milan, Italy.
microbio@mailserver.unimi.it
In this study the antibacterial and antifungal properties of propolis, a
natural product of bees, have been investigated against different pathogens.
Minimum inhibitory concentrations (MICs) and minimum bactericidal
concentrations (MBCs) were determined according to NCCLS standards on 320
strains including Staphylococcus aureus, Group A beta-hemolytic streptococci,
Streptococcus pneumoniae, Moraxella catarrhalis, Haemophilus influenzae,
Klebsiella pneumoniae, Escherichia coli, Proteus mirabilis, Pseudomonas
aeruginosa and Candida albicans. Time-kill curves were assessed for susceptible
microorganisms, testing 0, 0.5, 1, 2, 4 x MIC for propolis, by counting viable
bacteria after 0, 3, 6, 24 hours and viable yeasts after 0, 3, 6, 24 and 48
hours. Propolis showed good antimicrobial activity against most of the
isolates, particularly S. pneumoniae, H. influenzae and M. catarrhalis, but not
against Enterobacteriaceae. Time-kill curves demonstrated bacteriostatic rather
than bactericidal activity of propolis, the latter being evident only at high
concentrations.
PMID: 11128558 [PubMed - indexed for MEDLINE]
|
28:
Z
Naturforsch [C]. 2000 Sep-Oct;55(9-10):785-9. |
Chemical composition and
biological activity of propolis from Brazilian meliponinae.
Velikova M, Bankova V, Marcucci MC, Tsvetkova I, Kujumgiev A.
Institute of Organic Chemistry with Centre of Phytochemistry, Bulgarian Academy
of Sciences, Sofia.
Twenty-one propolis samples produced by 12 different Meliponinae species were
analyzed by GC-MS. Several chemical types of stingless bees' propolis could be
grouped, according to the prevailing type of compounds like: 'gallic
acid", "diterpenic" and "triterpenic" types. The results
confirm that neither the bee species nor the geographical location determine
the chemical composition of Meliponinae propolis and the choice of its plant
source, respectively. This could be explained by the fact that Meliponinae
forage over short distances (maximum
PMID: 11098831 [PubMed - indexed for MEDLINE]
|
29:
Parassitologia.
1999 Dec;41(4):587-90. |
Antifungal activity of
Apulia region propolis.
Cafarchia C, De Laurentis N,
Milillo MA, Losacco V, Puccini V.
Department of Animal Health and Welfare, Faculty of Veterinary Medicine,
University of Bari, Italy.
A study was carried out to assess the in vitro antifungal activity of some
natural Apulian propolis extracts of different origin. Their antifungal activity
was compared to the antifungal activity of conifers and commercial propolis
extracts. All extracts revealed antifungal activity against dermatophytes and
Candida species. The antifungal activity differences found depended on the
origin of the propolis and the solvent used for extraction. The best antifungal
activity was given by the 'Orimini' propolis. The antifungal activity may have
been influenced by the presence of different cinnamic and flavonoid components
and their different concentration in the extracts. Further investigations are
needed to validate this hypothesis.
PMID: 10870567 [PubMed - indexed for MEDLINE]
|
30:
Z
Naturforsch [C]. 2000 Jan-Feb;55(1-2):70-5. |
Chemical composition and
antimicrobial activity of European propolis.
Hegazi AG, Abd El Hady FK,
Abd Allah FA.
Department of Parasitology, National Research Center, Dokki, Giza, Egypt. ahmedgaffer@frcu.eun.eg
Three propolis samples from Austria, Germany and France were investigated by
GC/MS, where eleven compounds were being new for propolis. The samples showed
some similarities in their qualitative composition. Phenylethyl-trans-caffeate,
benzyl ferulate and galangin were predominant in German propolis. Benzyl
caffeate was predominant in French sample. Pinocembrin was predominant in
French and Austrian propolis and trans-p-coumaric acid was predominant in all
samples. The antimicrobial activity against Staphylococcus aureus; Escherichia
coli, and Candida albicans was evaluated. German propolis showed the highest
antimicrobial activity against Staphylococcus aureus and Escherichia coli.
While Austrian propolis has the highest activity against Candida albicans.
French propolis was effective against all pathogens but less than German and
Austrian propolis.
PMID: 10739103 [PubMed - indexed for MEDLINE]
|
31:
Arch
Oral Biol. 2000 Feb;45(2):141-8. |
In vitro antimicrobial
activity of propolis and Arnica montana against oral pathogens.
Koo H, Gomes BP, Rosalen PL, Ambrosano GM, Park YK, Cury JA.
School of Dentistry of Piracicaba, State University of Canipinas, Areiao, S.P.,
Brazil.
Arnica and propolis have been used for thousands of years in folk medicine for
several purposes. They possess several biological activities such as
anti-inflammatory, antifungal, antiviral and tissue regenerative, among others.
Although the antibacterial activity of propolis has already been demonstrated,
very few studies have been done on bacteria of clinical relevance in dentistry.
Also, the antimicrobial activity of Arnica has not been extensively
investigated. Therefore the aim here was to evaluate in vitro the antimicrobial
activity, inhibition of adherence of mutans streptococci and inhibition of
formation of water-insoluble glucan by Arnica and propolis extracts. Arnica
montana (10%, w/v) and propolis (10%, w/v) extracts from Minas Gerais State
were compared with controls. Fifteen microorganisms were used as follows:
Candida albicans--NTCC 3736, F72; Staphylococcus aureus--ATCC 25923;
Enterococcus faecalis--ATCC 29212; Streptococcus sobrinus 6715; Strep.
sanguis--ATCC 10556; Strep. cricetus--HS-6; Strep. mutans--Ingbritt 1600;
Strep. mutans--OMZ 175; Actinomyces naeslundii--ATCC 12104, W 1053; Act.
viscosus OMZ 105; Porphyromonas gingivalis; Porph. endodontalis and Prevotella
denticola (the last three were clinical isolates). Antimicrobial activity was
determined by the agar diffusion method and the zones of growth inhibition were
measured. To assess cell adherence to a glass surface, the organisms were grown
for 18 h at 37 degrees C in test-tubes at a 30 degree angle. To assay
water-insoluble glucan formation, a mixture of crude glucosyltransferase and
PMID: 10716618 [PubMed - indexed for MEDLINE]
|
32:
Z
Naturforsch [C]. 1999 May-Jun;54(5-6):401-5. |
Phytochemical evidence for
the plant origin of Brazilian propolis from Sao Paulo state.
Bankova V, Boudourova-Krasteva G,
Sforcin JM, Frete X, Kujumgiev A, Maimoni-Rodella R,
Popov S.
Institute of Organic Chemistry, Bulgarian Academy of Sciences, Sofia, Bulgaria.
IOCHNP@BGCICT.ACAD.BG
Propolis and plant secretions from three species, most frequently mentioned as
botanical sources of the bee glue in Brazil (Baccharis dracunculifolia,
Araucaria angustifolia and Eucalyptus citriodora) have been investigated using
GC-MS. Based on chemical evidence, B. dracunculifolia was shown to be the main
propolis source in Sao Paulo state. The antibacterial and antifungal activities
of all four materials were also tested, the most active being propolis and
Baccharis leaf exudate.
PMID: 10431391 [PubMed - indexed for MEDLINE]
|
33:
J Nat
Prod. 1999 Jul;62(7):1013-5. |
A polyisoprenylated
benzophenone from Cuban propolis.
Rubio OC, Cuellar Cuellar A,
Rojas N, Castro HV, Rastrelli L, Aquino R.
Institute for Pharmacy and Food (IFAL), University of Havana, Ave. 23, 21425,
Lisa, C. Habana, Cuba.
A novel polyisoprenylated benzophenone (1) has been isolated from an ethanol
extract of Cuban propolis. Its structure has been determined using high-field
2D NMR techniques. Compound 1 showed significant antimicrobial and antifungal
activity against a variety of bacteria and yeasts.
PMID: 10425129 [PubMed - indexed for MEDLINE]
|
34:
J
Ethnopharmacol. 1999 Mar;64(3):235-40. |
Antibacterial, antifungal
and antiviral activity of propolis of different geographic origin.
Kujumgiev A, Tsvetkova I, Serkedjieva Y,
Bankova V, Christov R, Popov S.
Institute of Microbiology, Bulgarian Academy of Sciences, Sofia.
Propolis samples from different geographic origins were investigated for their
antibacterial (against Staphylococcus aureus and Escherichia coli), antifungal
(against Candida albicans) and antiviral (against Avian influenza virus)
activities. All samples were active against the fungal and Gram-positive
bacterial test strains, and most showed antiviral activity. The activities of
all samples were similar in spite of the differences in their chemical composition.
In samples from the temperate zone, flavonoids and esters of phenolic acids are
known to be responsible for the above mentioned activities of bee glue;
tropical samples did not contain such substances but showed similar activities.
Obviously, in different samples, different substance combinations are essential
for the biological activity of the bee glue. It seems that propolis has general
pharmacological value as a natural mixture and not as a source of new powerful
antimicrobial, antifungal and antiviral compounds.
PMID: 10363838 [PubMed - indexed for MEDLINE]
|
35:
Folia
Microbiol (Praha). 1998;43(2):156-60. |
Use of propolis and
ultragriseofulvin to inhibit aflatoxigenic fungi.
Ghaly MF, Ezzat SM, Sarhan MM.
Botany Department, Faculty of Science, Zagazig University, Egypt.
Propolis ethanolic extract (PEE) at 3 and 4 g/L and ultragriseofulvin (UG) at
0.75 and 1 g/L reduced the percentage of conidia germination in two Aspergillus
flavus isolates. PEE at 1-4 g/L decreased the mycelial dry mass of A. flavus
isolates by 11-80%, and aflatoxin B1 production by 34-100%. UG concentrations
of 0.25-1 g/L reduced the growth and aflatoxin B1 production of the isolates by
16-88 and 48-98%, respectively. Any increase in PEE and UG concentration was
accompanied by a clear decrease in the per cent conidia germination, growth and
aflatoxin B1 production. At equal concentration, UG was about 4-times more
effective than PEE.
PMID: 9721607 [PubMed - indexed for MEDLINE]
|
36:
Tsitol
Genet. 1996 Nov-Dec;30(6):48-55. |
[The antimutagenic action
of apiculture products]
[Article in Russian]
Bariliak IR, Berdyshev GD, Dugan AM.
Using the battery of test-systems, we studied the possible antimutagenic
activity of some products of apiculture. It is established that
apilak-preparation made on the basis of queen bee milk didn't show
gene-protective abilities in Ames test. The rest products of apiculture:
propolis, beebread, honey preparations N1 and N2, and queen bee milk manifested
to some degree their ability to decrease the mutagenic effects of some chemical
and physical mutagens. The toxic effect of propolis upon yeast cells was
established. Queen bee milk manifested the least antimutagenic properties (on
all test-objects used in experiments).
PMID: 9139438 [PubMed - indexed for MEDLINE]
|
37:
Microbios.
1990;62(250):19-22. |
Antibiotic activity of
natural products: 1. Propolis.
Brumfitt W, Hamilton-Miller JM,
Franklin I.
Department of Medical Microbiology, Royal Free Hospital, Hampstead, London,
Great Britain.
Material extracted from propolis (bee glue) by alkaline aqueous solvents or
organic solvents showed weak inhibitory activity in vitro against certain
species of Gram-positive bacteria. No antimicrobial activity was detected in
urine from three volunteers who had taken 500 mg propolis three times a day for
3 days.
PMID: 2110610 [PubMed - indexed for MEDLINE]
|
38:
Rev
Chir Oncol Radiol O R L Oftalmol Stomatol Ser Stomatol. 1989
Apr-Jun;36(2):91-8. |
[Apiphytotherapeutic
original preparations in the treatment of chronic marginal parodontopathies. A
clinical and microbiological study]
[Article in Romanian]
Gafar M, Dumitriu H, Dumitriu S, Guti L.
The paper presents results obtained by the treatment of chronic marginal
parodontopathies with natural products of apiarian derivatives and vegetal
extracts. These are original preparations such as Proparodont, sage extracts,
watercress extracts, etc., by comparison with other similar existing products,
and with zinc chloride. The clinical study evaluated the "inflammation
status of the marginal prodontium" on the basis of variations in the PMA
index. The microbiological study has established the bacteriostatic and the bactericidal
activities of the products employed. The results obtained stress the high
antimicrobial activity of the original products called Proparodont, and stress
its antimycotic effects, especially against Candida albicans. The blackwort
(Symphytum off.) extracts have a good repair effect, especially after surgical
procedures. The complex original products based on propolis and vegetal
extracts are indicated in the treatment of inflammatory lesions of the
gingivo-parodontal tissues, and of the buccal mucosa. They also have
antimicrobial effects, as well as antimycotic, antiinflammatory and antiscar
effects. They de not have side effects which are characteristic for other
medicinal drugs employed in the treatment of chronic marginal parodontopathies.
PMID: 2535077 [PubMed - indexed for MEDLINE]
|
39:
Minerva
Med. 1983 Sep 15;74(35):2029-32. |
[Bacteriological and
clinical notes on otitis externa in saturation. Double-blind study on the
efficacy of prophylactic and therapeutic preparations]
[Article in Italian]
Marroni A, Arduini R, Conti S.
Microbiological analysis of the variation in the bacterial flora of the
external auditory canal was carried out during 39 immersion in saturated
solutions. A double blind test on the usefulness of prophylactic and
therapeutic preparations was also carried out. Prophylactics. - 5% Al acetate
in H2O (P1), Boric alcohol (P2), lactic acid in H2O (P3, Domeboro (P4), no
prophylactic (P0). After the immersions, a significant increase in Pseudomonas
Aeruginosa and Candida Albicans (p less than 0,01) was noted in the auricular
bacterial flora. Gram positive bacteria in general were considerably reduced (p
less than 0,01). Gram negative bacteria other than pseudomonas. A (p less than
0,3) and coagulase negative straphylococci (p less than 0,03) did not vary
significantly. Prophylactic preparations P1 and P2 were shown to be
significantly more effective than P3, P4 and P0 in preventing the
symptomatology (p less than 0,01). The most effective therapeutic preparation
was found to be a locally applied gentamycinpolymixin association.
Publication Types:
PMID: 6412179 [PubMed - indexed for MEDLINE]
|
40:
Pharmazie.
1982 Jun;37(6):439-40. |
Inhibition of growth and
biosynthesis of ochratoxin A in Aspergillus sulphureus NRRL 4077 by propolis
extract.
Pepeljnjak S, Jalsenjak I, Maysinger D.
Growth inhibition of Aspergillus sulphureus NRRL 4077 and biosynthesis of
ochratoxin A in the presence of propolis was investigated. Although the growth of
the micro-organism was inhibited at all concentrations of applied propolis
extract up to d 10 of incubation, only the 2.0 mg/ml concentration of propolis
exhibited definite fungistatic activity. Ochratoxin A was detected in all
culture media, but its amounts were low in the first 10 d of experiment. In
comparison with the control culture, the amounts of ochratoxin A were
proportional to the growth of A. sulphureus and reciprocal to the amounts of
propolis extract used.
PMID: 7122687 [PubMed - indexed for MEDLINE]
|
41:
Pharmazie.
1979;34(2):97-102. |
[On the antimicrobial
activity of propolis and propolis constituents (author's transl)]
[Article in German]
Metzner J, Bekemeier H, Paintz M, Schneidewind E.
After a survey of the literature on the antimicrobial activity of the bee
product propolis, the authors discuss their own findings as compared to the
chemotherapeutical agents streptomycin, oxytetracycline, chloramphenicol,
nystatin, griseofulvin and sulphamerazine. According to the results obtained by
testing 25 isolated constituents on Bacillus subtilis, Staphylococcus aureus,
Candida albicans and Trichophyton mentagrophytes, the antimicrobial properties
of this mixture of natural substances are mainly attributable to the flavonoids
pinocembrin, galangin, pinobanksin, pinobanksin-3-acetate as well as to the
p-coumaric acid benzyl ester and a caffeic acid ester mixture. None of the
isolated substances was as potent as the antibiotics tested for the purpose of
comparison. The relatively good antimycetic activity of the
5,7-dihydroxyflavanone pinocembrin seems noteworthy. Finally, possible
mechanisms of the antimicrobial action of the flavonoids are discussed.
PMID: 108687 [PubMed - indexed for MEDLINE]
|
42:
Pharmazie.
1977 Nov;32(11):730. |
[Effect of propolis and
pinocembrin on fungi]
[Article in German]
Metzner J, Schneidewind EM,
Friedrich E.
PMID: 609603 [PubMed - indexed for MEDLINE]
|
43:
Antibiotiki.
1976 May;21(5):422-3. |
[Fractionation of the
mixture of volatile with steam components of propolis and the study of their
antimicrobial activity]
[Article in Russian]
Kivalkina VP, Rybkina NI, Barskov AA, Geras'kin IM, Talan VA.
PMID: 828845 [PubMed - indexed for MEDLINE]
|
44:
Pharmazie.
1976;31(1):55. |
[Action of propolis on
dermatophytes]
[Article in German]
Cizmarik J, Trupl J.
PMID: 1257286 [PubMed - indexed for MEDLINE]
|
45:
Pharmazie.
1975 Jun;30(6):406-7. |
[The action of propolis on saccharomycetes]
[Article in German]
Cizmarik J, Trupl J.
PMID: 1099582 [PubMed - indexed for MEDLINE]
|
46:
Pharmazie.
1975 Dec;30(12):799-800. |
[Bioautographic detection of the antimicrobial active constituents of
propolis]
[Article in German]
Metzner J, Bekemeier H, Schneidewind E, Schwaiberger R.
PMID: 815918 [PubMed - indexed for MEDLINE]
|
47:
Pharmazie.
1975 Dec;30(12):803. |
[The constitutents of propolis]
[Article in German]
Schneidewind EM, Kala H, Linzer B, Metzner J.
PMID: 768996 [PubMed - indexed for MEDLINE]