PROPOLEO Y HERPES
|
Items 1 - 9 of 9 |
One page. |
|
1: Isr Med Assoc J. 2002 Nov;4(11 Suppl):923-7. |
Anti-herpes simplex virus effect of an aqueous
extract of propolis.
Huleihel M, Isanu V.
Institute for Applied Biosciences,
BACKGROUND: Propolis, a natural product from
beehives, comprises a complex of chemicals, the most
important group being flavinoids, which play a role
in antiviral protection. OBJECTIVES: To test the inhibitory effect of propolis extract against herpes simplex viruses in vitro
and in vivo. METHODS: In vitro: propolis was added to
Vero cells at various times and concentrations before, at or after infection
with HSV-
PMID: 12455181 [PubMed
- indexed for MEDLINE]
|
2:
Phytomedicine. 2000 Mar;7(1):1-6. |
A comparative multi-centre study of the efficacy
of propolis, acyclovir and placebo in the treatment
of genital herpes (HSV).
Vynograd N, Vynograd I, Sosnowski Z.
Ninety men and women with recurrent genital HSV type 2 participated in a
randomized, single-blind, masked investigator, controlled multi-centre study
comparing the efficacy of ointment of Canadian propolis
containing natural flavonoids with ointments of
acyclovir and placebo (vehicle) on healing ability and capacity to remedy
symptoms. Thirty individuals were randomized to each group. Treatment was
intended to start in the blister phase. All participants had HSV type 2
isolated, confirmed by serum immunoglobulin levels. The participants were
examined on the 3rd, 7th and 10th days of treatment by gynaecologists, dermatovenerologists or urologists at seven different
medical centres. Apart from clinical symptoms the number and size of the herpetic
lesions were noted. At each examination the lesions were classified into four
stages: vesicular, ulcerated, crusted and healed. The study ointments were
applied to affected areas four times daily. In women with vaginal or cervical
lesions a tampon with the appropriate ointment was inserted four times daily
for 10 days. Endpoint variables were healing time and time until loss of
symptoms. RESULTS: On Day 10, 24 out of 30 individuals in the propolis group had healed. In the acyclovir group 14 out of
30 and in the placebo group 12 out of 30 had healed. (p = 0.0015). The healing
process appeared to be faster in the propolis group. In
the propolis group 15 individuals had crusted lesions
on Day 3 compared to 8 individuals in the acyclovir group and none in the
placebo group (p = 0.0006). On Day 7, 10 participants in the propolis group,
Publication Types:
PMID: 10782483 [PubMed - indexed for MEDLINE]
|
3:
Voen Med Zh.
1995 Dec;(12):36-9, 80. |
[The use of ocular drug films of propolis in
the sequelae of ophthalmic herpes]
[Article in Russian]
Maichuk IuF, Orlovskaia LE, Andreev VP.
There was studied the therapeutic efficiency of ocular medical propolis films (OMF) in 35 patients with postherpetic trophic keratitis and in 20 with postherpetic
nebula. OMF were applied behind the lower eyelid at bedtime during 10-15 days. All
the patients endured the propolis films well. OMF
accelerated the cornea epithelization. Epitheliopathy and micropoint edema of cornea epithelium rapidly disappeared. Time of
patients recovery reduced nearly twice (P,001) in
comparison with the control group--from 14.1 to 7.6 days. On the average their
visual acuity increased in two times--from 0.12 to 0.27 (P > 0.001).
PMID: 8779164 [PubMed
- indexed for MEDLINE]
|
4:
J Nat Prod. 1994 May;57(5):644-7. |
Comparison of the anti-herpes simplex
virus activities of propolis and 3-methyl-but-2-enyl caffeate.
Amoros
M, Lurton
E, Boustie
J, Girre
L, Sauvager
F, Cormier
M.
Laboratoire de Pharmacognosie
et Mycologie.
The in
vitro activity against herpes simplex virus type 1 of 3-methyl-but-2-enyl caffeate isolated from poplar buds or prepared by synthesis
was investigated. Under conditions of one or multiple multiplication cycles,
this compound, which is a minor constituent of propolis,
was found to reduce the viral titer by 3 log10, and
viral DNA synthesis by 32-fold.
PMID: 8064297 [PubMed
- indexed for MEDLINE]
|
5:
J Nat Prod. 1992 Dec;55(12):1732-40. |
Synergistic effect of flavones and flavonols against herpes simplex virus type
Amoros M, Simoes CM, Girre L, Sauvager F, Cormier M.
Laboratoire de Pharmacognosie et Mycologie, Faculte de Pharmacie, Universite de Rennes I, France.
The in
vitro activity against herpes simplex virus type 1 of the major flavonoids identified in propolis
was investigated. Flavonols were found to be more
active than flavones, the order of importance being galangin,
kaempferol, and quercetin. The
efficacy against HSV-1 of binary flavone-flavonol
combinations has been also investigated. The synergy demonstrated by all
combinations could explain why propolis is more
active than its individual compounds.
PMID: 1338212 [PubMed
- indexed for MEDLINE]
|
6:
Microbiologica. 1990 Jul;13(3):207-13. |
Effects of propolis
flavonoids on virus infectivity and replication.
Debiaggi
M, Tateo
F, Pagani
L, Luini
M, Romero E.
Istituto di Microbiologia, Universita degli
The effect of five propolis flavonoids
on the infectivity and replication of some herpesvirus,
adenovirus, coronavirus and rotavirus strains has
been studied. Experiments were performed in vitro in cell cultures using the
viral plaque reduction technique. The cytotoxicity of
flavonoids, including chrysine,
kaempferol, acacetin, galangin and quercetin, was
evaluated on uninfected monolayers to determine their
effect on cell growth and viability. Chrysine and kaempferol caused a concentration-dependent reduction of
intracellular replication of herpes-virus strains when monolayers
were infected and subsequently cultured in a drug-containing medium. However,
virus infectivity was not significantly affected. Acacetin
and galangin had no effect on either the infectivity
or replication of any of the viruses studied. Quercetin
reduced infectivity and intracellular replication, but only at the highest
concentrations tested.
PMID: 2125682 [PubMed
- indexed for MEDLINE]
|
7:
Virologie. 1988 Jan-Mar;39(1):21-4. |
[Treatment of cutaneous herpes and herpes zoster
with Nivcrisol-D]
[Article in French]
Giurcaneanu F, Crisan I, Esanu V, Cioca V, Cajal N.
Hopital Colentina, Service de Dermatologie,
Bucarest, Roumanie.
The results obtained at the Dermatological service of the
PMID: 3376426 [PubMed
- indexed for MEDLINE]
|
8:
Virologie. 1984 Oct-Dec;35(4):281-93. |
Research in the field of antiviral chemotherapy performed in the
"Stefan S. Nicolau" Institute of Virology.
Esanu V.
A brief review is made of the research in the field of antiviral chemotherapy
performed in the "Stefan S. Nicolau"
Publication Types:
PMID: 6097022 [PubMed - indexed for MEDLINE]
|
9:
Virologie. 1981 Jan-Mar;32(1):57-77. |
Recent advances in the chemotherapy of herpes virus infections.
Esanu V.
The main categories of antiherpes agents presently
used in chemotherapy area reviewed according to the phase of virus replication affected : 1) virus adsorption (adamantane,
nonionic surfactants) ; 2) eclipse (interferon) ; 3) virion maturation (nucleoside and nucleotide analogues and phosphonic acid derivatives). Mention is also made of other
compounds--different synthetic organic derivatives, photodynamic dyes, metal
ions, boric acid, hormones, antibiotics, other natural products (extracts from
marine algae, propolis, garlic)--with
promising antiviral properties. The difficulties and prospects of viral
chemotherapy research are briefly discussed.
Publication Types:
·
Review
PMID: 6191437 [PubMed - indexed for MEDLINE]